The disillusioned general of an ancient Chinese army regiment finds himself stranded in a village populated by a strange clan with mystical connections to wolves.

Ginko, a Mushi-shi has always been attuned to the Mushi, creatures close to life itself and able to affect and alter their surroundings. He cannot stay in one place for too long so he wanders, helping the inhabitants of rural Japan understand the Mushi around them and how to coexist peacefully.

In Kagoshima, the boy Koichi lives with his mother Nozomi in the house of his grandparents. Koichi misses his younger brother Ryunosuke and his father Kenji, who live in Fukuoka, and he dreams on his family coming together again. One day, Koichi overhears that the energy released by two bullet trains passing by each other would grant wishes and he invites his two best friends, Tasuku and Makoto, to travel to the point of intersection of the two trains. Koichi also tells his plan to Ryunosuke that invites his three best friends to join him. Soon the seven children arrive to the meeting point in the journey of discoveries.

In war-torn Japan, the Tokugawa Shogun, desperate to restore peace to his people, orders the assassination of the hostile warlords. A beautiful young woman is raised from birth with nine other orphans, to become an assassin. Her name is AZUMI, the ultimate assassin.